Immune monitoring in clinical multicenter trials

FOCUS Immunology has developed methods for on-site isolation of immune cells from peripheral blood, their transportation to Heidelberg, and subsequent functional testing under conditions of international multicenter clinical trials.

In a recent project patients were recruited at medical centers in several countries. At these sites FOCUS implemented its robust and simple protocol for on-site cell preparation. Then FOCUS organised the controlled transportation of the cells to the central testing laboratory in Heidelberg, Germany.

Incoming samples were QC-ed, and cytokine production as well as proliferation was determined in cultures of the isolated immune cells together with various defined stimuli of immune functions.

It took FOCUS only 6 weeks to implement standardized sample generation, sample logistics and testing.

The studies led to further understanding of the compound’s mode-of-action.

FOCUS Immunology offers immune monitoring tailored to the needs of given clinical trial protocols. For further information please contact immunology@focus-cdd.com or contact directly FOCUS’ Head of the Immunology Laboratory Dr. Eddy Bruyns at eddy.bruyns@focus-cdd.com, Tel.: +49 (0) 6221 649 35 124.