T lymphocytes (T cells): measuring phenotype, activity and function

T lymphocytes (T cells) play a central role in the initiation and propagation of physiological and pathological immune responses. To exert their functions, resting T cells are activated, whereby the activation signals and pathways can be manifold and the resulting cellular functions are diverse.

Modern cell biological techniques allow to distinctively address the different activation pathways by specific stimulators and inhibitors, be it by specific antibodies against cell surface receptors (e.g. anti-CD3, or anti-CD28) or be it by chemical reagents (e.g. phorbol myristate acetate or ionomycin).

These sophisticated stimulation protocols can then be combined with appropriate analytical technologies to assess the phenotype and function of the activated cell populations, like expression of cell surface activation markers, secretion of cytokines, or proliferation.
FOCUS Immunology operates these technologies and tailors their use to the specific needs of a study protocol.

To learn more about FOCUS Immunology’s expertise and service offer in T cell biology contact us at immunology@focus-cdd.com or contact directly our Head of FOCUS Immunology Dr. Eddy Bruyns at eddy.bruyns@focus-cdd.com.

FOCUS Immunology laboratory is part of the Clinical Research Organisation (CRO) FOCUS-CDD GmbH. FOCUS Immunology provides immunological biomarker services under GLP and non-GLP conditions for the development of novel medicines.